pH dependent residues: Asp132, Glu137, and Glu141.
Image was created using Pymol version 1.3 with pdb1LS8 from Lee et al.
#Bombyx mori life cycle ppt movie
(2002) FEBS Letters 531, 314-318.ĬOOH-Terminus Tail Movie made using eMovie. Hodis, E., Schreiber, G., Rother, K., Sussman, J.L., eMovie: a storyboard-based tool for making molecular movies, Trends in Biochemical Sciences32, 199-204 (2007). Hydrophobic pocket “Lid” BmorPBP1 B-form (1LS8) BmorPBP1 A-form (1GM0) H95 Lid E98 H70 H95 H70 D63 E98 D63 Lid Images of BmorPBP1 Lid was created using Pymol version 1.3 with pdbs 1GM0 and 1LS8. Image was created using Pymol version 1.3 with pdb 1DQE from Sandler et al. Lid instability in low pH Movie made using eMovie. Hodis, E., Schreiber, G., Rother, K., Sussman, J.L., eMovie: a storyboard-based tool for making molecular movies, Trends in Biochemical Sciences32, 199-204 (2007).When protonated, possible interaction with Glu98 and Asp63.Histidine residues: H70 and H95 act as a pH-dependent switch.“Lid” is the loop region between α-helix 3 and α-helix 4.(2000) Chemistry & Biology 7, 142-151īmorPBP1 Hydrophobic Pocket Residues with bombykol (1DQE) Bombykol Display of BmorPBP1 hydrophobic pocket was created using Pymol version 1.3 and pdb: 1DQE. Closes hydrophobic binding pocket Movie made using eMovie. Hodis, E., Schreiber, G., Rother, K., Sussman, J.L., eMovie: a storyboard-based tool for making molecular movies, Trends in Biochemical Sciences32, 199-204 (2007).Image was created using Pymol version 1.3 with pdb 1DQE from Sandler et al.in 1993įirst Determined BmorPBP1 Structure via X-ray diffraction (1DQE) Sandler et al. BmorPBP1 was first isolated by Maida et al.Bombykol, first discovered sex pheromone, of Bombyx mori (Silk Moth) by Butenandt in 1959.Pheromone-binding proteins (PBPs) are used to transport pheromones, semiochemicals, from the outside environment through the aqueous sensillary lymph to dendritic-odorant receptors.Advanced Biochemistry and Molecular Biology I BCMB 8010 11/30/10īombykol Background of Pheromone-binding proteins Bombyx mori, domesticated silkmoth, Pheromone-Binding Protein 1 Presented by: Tommy W.
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